Vardenafil is white or grey crystallin powder. It is fast absorbed in blood (bioaccessibility is 15%). This substance is a selective inhibitor of 5-type cyclic guanosine monophosphate. Clinical effectiveness of this substance was tested on 805 men suffering from at least six-month erectile dysfunction. The age of men was between 18 and 89 years. All trial participants received special instructions concerning dietary regimen and medication intake. They took various doses of vardenafil during 3-12 months. Even patients with diabetes participated in this research study. It was confirmed that vardenafil-based medications restore sexual activity in 85% of cases.
After FDA approved sildenafil distribution in 1998, major players of pharmacological market started development of new remedies restoring potency. And the next ED drug was vardenafil. The medications acquired good reviews and occupied considerable part of the market. Men liked its relatively soft impact in organism and more long-term action.
While getting in organism, the medicine enhances blood stream to penis. There are two big cameras in penis where cavernous bodies are located. While enlargement and thickening due to imbued blood, penis gets erected. It is important to vasodilate vessels and enhance blood supply locally. In order to prevent from constant erection and its occurrence only with stimulation, the afore-mentioned process is blocked by penile unstriated muscles. Cyclic guanosine monophosphate is responsible for relaxation of unstriated muscles of penis. It gets formed in cavernous bodies due to release of nitrogen oxide. Specific enzyme, PDE5, prevents from level increase of cyclic guanosine monophosphate in blood in case of impairments of sexual system. Vardenafil is dedicated for blockage of this enzyme.
Vardenafil is of similar effect with sildenafil. But in comparison with the latter one, it has a softer and more delicate impact. During clinical trials it was stated that maximal concentration of active substance in blood plasma in observed in 2-3 hours. In the majority of cases, drug’s action is observed within 6-8 hours. Vardenafil pills are also used like other PDE5 inhibitors. Structurally, formula of this substance differs from sildenafil only by location of nitrogen atom. Mainly, vardenafil-containing medications are prescribed for therapy of erectile dysfunction (impotency). Besides, this medicine may be effectively used in struggle against premature ejaculation.
Generally, vardenafil takes its action in 15 minutes after intake. Effect occurrence is observed in 25-30 minutes. There is a number of factors (fatty food, depression, etc.) that are able to delay the onset time. Therefore, doctors recommend taking vardenafil approximately one hour prior to sexual activity. Tablet is to be drunk with water to allow an organism to absorb active substance and clear it faster. The medicine’s action may last from 5-6 to 8-12 hours. Maximal daily dose is one pill a day. Vardenafil content in tablets may be 2,5; 5; 10; 20mg. Most men start taking vardenafil in the dose of 10mg. Scientists state that such dosage is equivalent to 50mg of sildenafil.
Vardenafil (like any other drug) is possible in case of severe overdose. Vardenafil containing drugs belong to medications of new generation. It is well known that sildenafil is incompatible with alcoholic beverages. Anyway, one of Levitra’s advantages is compatibility with alcohol. Medicine’s intake may be combined with 5 glasses of wine, for example.